Kaftrio* (elexacaftor/tezacaftor/ivacaftor)

Kaftrio* (elexacaftor/tezacaftor/ivacaftor) for sale – Buy Kaftrio* (elexacaftor/tezacaftor/ivacaftor) Online

What is Kaftrio (elexacaftor/tezacaftor/ivacaftor)* for?

Kaftrio (elexacaftor/tezacaftor/ivacaftor)* is a medication used in combination with ivacaftor 150 mg tablets for people with cystic fibrosis (CF) aged 12 years and older with at least one copy of the F508del mutation.

How effective is Kaftrio (elexacaftor/tezacaftor/ivacaftor)* for cystic fibrosis?

The approval of Kaftrio (elexacaftor/tezacaftor/ivacaftor)* for CF was based on two clinical studies.

Study 1

Included 403 people with CF, 12 years and older, with one copy of the F508del mutation and a mutation defined in the study. Kaftrio was compared with placebo (a dummy treatment).

According to the study results published:

After 24 weeks, lung function (FEV1) improved significantly.

Study 2

Included 107 people with CF, 12 years and older, with two copies of the F508del mutation. Kaftrio and ivacaftor was compared with ivacaftor and tezacaftor (Symdeko).

According to the study results published:

There was significant improvement in lung function (FEV1).

For more details refer to the prescribing information at the bottom of the page.

Which side effects can I expect with Kaftrio (elexacaftor/tezacaftor/ivacaftor)*?

According to the studies published ,the main common side effects of Kaftrio (which may affect more than 1 in 10 people) in people with CF aged 12 years and older include headaches, upper respiratory tract infections, abdominal pains, diarrhea and rashes.

Please note this is not intended to be a comprehensive guide. Consult your treating doctor and the prescribing information at the bottom of the page for full details of side effects.

How is Kaftrio (elexacaftor/tezacaftor/ivacaftor)* taken?

Administration: in the morning take two Kaftrio tablets. In the evening, take one ivacaftor tablet. Take these tablets approximately 12 hours apart.

Dosage: 150 mg ivacaftor, 100 mg tezacaftor and 200 mg elexacaftor in the morning and 150 mg ivacaftor in the evening.

Each dose must be taken with fat-containing food.

Please note this is not intended to be a treatment plan. For a personalised treatment plan, consult your doctor. For more details, you can also reference the full prescribing information at the bottom of the page.

Frequently Asked Questions about Kaftrio (elexacaftor/tezacaftor/ivacaftor)*

Downloads

Patient guide Kaftrio vs Trikafta – Differences and administration

Package leaflet – Information for the patient

References

1. Kaftrio (elexacaftor/ivacaftor/tezacaftor) [PDF].
Vertex Pharmaceuticals Incorporated, Aug 21, 2020.

2. New medicine for cystic fibrosis patients.
European Medicines Agency press release 26/06/2020.

3. Full prescribing information [FDA]: Trikafta (elexacaftor/ivacaftor/tezacaftor) [PDF].
Vertex Pharmaceuticals Incorporated, Oct 2019.

*Kaftrio (elexacaftor/tezacaftor/ivacaftor) is a registered trademark by Vertex Pharmaceuticals Incorporated.